Dr. Manning and Dr. Charles treat a teenage girl with a rapidly changing set of symptoms that has everyone perplexed. Dr. Choi and medical student Jeff Clark encounter a 19 year-old tough guy who is brought into the hospital in severe distress. Once they establish the cause of the pain, the situation quickly turns dangerous and a resolved Dr. Reese does her best to help. Elsewhere, Dr. Latham makes a big admission to Dr. Rhodes while Dr. Halstead must deal with a difficult case that is further complicated by Dr. Stohl, who has a camera crew following him around to shoot a promotional video spotlighting the hospital.
The newest installment of the compelling 'Chicago' franchise, an emotional thrill ride through the day-to-day chaos of the city's most explosive hospital and the courageous team of doctors who hold it together. They will tackle unique new cases inspired by topical events, forging fiery relationships in the pulse-pounding pandemonium of the emergency room, and through it all, familiar faces from the Chicago police and fire departments will intertwine as this third team of Chicago heroes hits the ground running.