Dr. Manning and fourth-year medical student Jeff Clarke are forced to figure out a mystery illness when an Indonesian man who doesn't speak English arrives at the hospital in dire straights. Maggie takes Dr. Halstead to her family reunion where he meets her sibling Denise and uncovers deep-rooted family secrets. Meanwhile, Dr. Rhodes takes on a complicated heart surgery without consulting Dr. Latham and Dr. Reese and Dr. Charles encounter a woman experiencing an unusual pregnancy.
The newest installment of the compelling 'Chicago' franchise, an emotional thrill ride through the day-to-day chaos of the city's most explosive hospital and the courageous team of doctors who hold it together. They will tackle unique new cases inspired by topical events, forging fiery relationships in the pulse-pounding pandemonium of the emergency room, and through it all, familiar faces from the Chicago police and fire departments will intertwine as this third team of Chicago heroes hits the ground running.