A car accident that occurs at the Chicago Marathon leaves a victim in critical condition and tests the mettle of Dr. Halstead, April and her fourth-year medical resident brother Noah, who must perform a difficult procedure in the field. A mother brings in her 8-year-old girl experiencing a sudden hearing loss, and Dr. Manning is left to tend to the case, which takes a complicated turn. Dr. Choi deals with Olga, a woman who is malnourished, prompting him to bring in Dr. Charles to help assess the case. Meanwhile, Goodwin takes measures to get her personal life in order.
The newest installment of the compelling 'Chicago' franchise, an emotional thrill ride through the day-to-day chaos of the city's most explosive hospital and the courageous team of doctors who hold it together. They will tackle unique new cases inspired by topical events, forging fiery relationships in the pulse-pounding pandemonium of the emergency room, and through it all, familiar faces from the Chicago police and fire departments will intertwine as this third team of Chicago heroes hits the ground running.