Dr. Rhodes convinces Dr. Latham to join him for a medical trip out of town, which puts Latham's personality issues to the test. Dr. Manning treats an 8 year-old cancer patient who wants to give up on his battle until she makes a surprise discovery. Elsewhere, an unhealthy woman with heart problems is brought in and doesn't want to listen to doctors, much to the dismay of Dr. Halstead. Meanwhile, Dr. Choi, Dr. Charles and Dr. Reese work on a complicated case involving a woman with a personality disorder. Will and Nina work through their first relationship test.
The newest installment of the compelling 'Chicago' franchise, an emotional thrill ride through the day-to-day chaos of the city's most explosive hospital and the courageous team of doctors who hold it together. They will tackle unique new cases inspired by topical events, forging fiery relationships in the pulse-pounding pandemonium of the emergency room, and through it all, familiar faces from the Chicago police and fire departments will intertwine as this third team of Chicago heroes hits the ground running.