On the way back to Hearthome City, Ash and friends stop in Solaceon Town. After reading about a monster in a local paper, they decide to go searching for it. While looking they run into their Summer Academy friend Angie at her parents daycare center. There they discover that the monster in town is partially Angie's fault. They then agree to help her get the monster (which is really a Lickilicky) back before her parents get home.
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.