Ash and Paul's battle in the Sinnoh League quarter-finals rages on. Things are looking good for Ash, who has so far defeated Paul's Aggron and Gastrodon and still has all of his Pokémon remaining, but the tables start to turn when Paul sends out his new Drapion. Will Ash be able to hold his ground and defeat his Sinnoh Region rival once and for all?
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.