In a dark alley three kids come face to face with the mysterious "Red Lighting". One kid sends out his Poliwag only to have it beaten and scribbled on. Then, Ash and the others arrive in the same city. Nurse Joy tells them of Red Lighting and how he is unbeatable. While visiting a park, May's Squirtle runs off and is attacked by Red Lighting and is easily defeated. After following Red Lighting to a house on the top of a skyscraper, they find out it is just a Scizor that belongs to a little girl, however she has no plans to stop her little plan. Now Ash decides to stop her for good.
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.