George is given the responsibility of watching Tansy's most prized possession, her dog, but panics when the dog goes missing. Wade starts to feel frustrated by the lack of alone time with Zoe, especially when she is focused more on not losing her good status in the town to a new doctor, Jonah, who also happens to be Brick's nephew. Brick is ready to let the town know about his relationship with Shelby, but Lemon and Magnolia are doing everything they can to get rid of her. Meanwhile, Lavon wants to take a chance on a new relationship, but first has to clear the air with one person.
Fast-talking New Yorker and brand new doctor Zoe Hart has it all figured out - after graduating top of her class from medical school, she'll follow in her father's footsteps and become a cardio-thoracic surgeon. But when her dreams fall apart, Zoe decides to accept an offer from a stranger, Dr. Harley Wilkes, to work with him at his small practice in Bluebell, Alabama. Zoe arrives in this small Gulf Coast town only to find that Harley has passed away and left his half of the medical practice to her in his will.
She quickly finds that Southern hospitality isn't always so hospitable - the other doctor in town, Brick Breeland, is less than pleased to be sharing the practice with this young outsider, and his daughter, Lemon, is a Southern belle whose sweet disposition turns sour when she meets Zoe. Zoe's only allies are the mayor, former football star Lavon Hayes, her bad-boy neighbor Wade Kinsella, and handsome lawyer George Tucker - who just happens to be Lemon's fiance. Zoe is out of her element and ready to pack her bags, but a surprise visit by her snobby New York mother leads to Zoe's decision to stay in Bluebell for a while, discovering small-town life and a side of herself she hadn't known was there.