Zoe is trying hard to stay away from Wade, but when Rose enlists her help in throwing the first BlueBellapalooza, she is forced to ask Wade to convince his old band mate to be the musical act on short notice. Wade convinces George to start playing the field and agrees to be his wingman, but when Wade stands him up, he decides to follow the seemingly questionable advice solo. Meanwhile, Brick tries to trick Lemon into working for him, but she is determined to keep her waitressing job, that is until one of her customers ends up needing medical attention.
Fast-talking New Yorker and brand new doctor Zoe Hart has it all figured out - after graduating top of her class from medical school, she'll follow in her father's footsteps and become a cardio-thoracic surgeon. But when her dreams fall apart, Zoe decides to accept an offer from a stranger, Dr. Harley Wilkes, to work with him at his small practice in Bluebell, Alabama. Zoe arrives in this small Gulf Coast town only to find that Harley has passed away and left his half of the medical practice to her in his will.
She quickly finds that Southern hospitality isn't always so hospitable - the other doctor in town, Brick Breeland, is less than pleased to be sharing the practice with this young outsider, and his daughter, Lemon, is a Southern belle whose sweet disposition turns sour when she meets Zoe. Zoe's only allies are the mayor, former football star Lavon Hayes, her bad-boy neighbor Wade Kinsella, and handsome lawyer George Tucker - who just happens to be Lemon's fiance. Zoe is out of her element and ready to pack her bags, but a surprise visit by her snobby New York mother leads to Zoe's decision to stay in Bluebell for a while, discovering small-town life and a side of herself she hadn't known was there.