Lavon's big plans of making BlueBell a Spring Break destination hits a roadblock when the competing town tries to lure the partiers away. With the help of Ruby Jeffries, Lavon creates a competition that is bound to attract some attention. Eager to join in some much-deserved fun, Zoe agrees to give partying a try with Jonah, but seeing them together makes George jealous. Wade and Lemon decide to compete in Lavon's contest in order to win the grand prize to buy the Rammer Jammer, which they have learned is for sale. Meanwhile, Brick has been acting odd and when everyone begins to notice they force him to seek treatment.
Fast-talking New Yorker and brand new doctor Zoe Hart has it all figured out - after graduating top of her class from medical school, she'll follow in her father's footsteps and become a cardio-thoracic surgeon. But when her dreams fall apart, Zoe decides to accept an offer from a stranger, Dr. Harley Wilkes, to work with him at his small practice in Bluebell, Alabama. Zoe arrives in this small Gulf Coast town only to find that Harley has passed away and left his half of the medical practice to her in his will.
She quickly finds that Southern hospitality isn't always so hospitable - the other doctor in town, Brick Breeland, is less than pleased to be sharing the practice with this young outsider, and his daughter, Lemon, is a Southern belle whose sweet disposition turns sour when she meets Zoe. Zoe's only allies are the mayor, former football star Lavon Hayes, her bad-boy neighbor Wade Kinsella, and handsome lawyer George Tucker - who just happens to be Lemon's fiance. Zoe is out of her element and ready to pack her bags, but a surprise visit by her snobby New York mother leads to Zoe's decision to stay in Bluebell for a while, discovering small-town life and a side of herself she hadn't known was there.