After Zoe treats the high school football team, she learns that Max, who happens to be Rose's new crush, has become infatuated with her instead. Eager to nip his crush in the bud, Zoe learns that Max is prone to overreacting to heartbreak and is encouraged by the town to wait until after the big game, as they are counting on him to win. Lemon decides to start a catering business and asks AnnaBeth to join, but Lemon is taken aback by her answer. Meanwhile, Lavon tries to win over Ruby's grandfather Sergeant Jeffries by doing his chores, but Lavon finds out there is another reason her grandfather doesn't want them together.
Fast-talking New Yorker and brand new doctor Zoe Hart has it all figured out - after graduating top of her class from medical school, she'll follow in her father's footsteps and become a cardio-thoracic surgeon. But when her dreams fall apart, Zoe decides to accept an offer from a stranger, Dr. Harley Wilkes, to work with him at his small practice in Bluebell, Alabama. Zoe arrives in this small Gulf Coast town only to find that Harley has passed away and left his half of the medical practice to her in his will.
She quickly finds that Southern hospitality isn't always so hospitable - the other doctor in town, Brick Breeland, is less than pleased to be sharing the practice with this young outsider, and his daughter, Lemon, is a Southern belle whose sweet disposition turns sour when she meets Zoe. Zoe's only allies are the mayor, former football star Lavon Hayes, her bad-boy neighbor Wade Kinsella, and handsome lawyer George Tucker - who just happens to be Lemon's fiance. Zoe is out of her element and ready to pack her bags, but a surprise visit by her snobby New York mother leads to Zoe's decision to stay in Bluebell for a while, discovering small-town life and a side of herself she hadn't known was there.