Wade struggles with feeling like he's a placeholder in Zoe's life, so he decides that they should go on a date. Despite Zoe's apprehensions, she decides to bid on Wade's basket at the upcoming charity picnic auction, but is surprised that she is not the only one interested. Lemon mistakenly wins Lavon's basket and decides to keep her true feelings for him to herself and instead offers some advice about his relationship with Ruby (guest star Golden Brooks). Meanwhile, George is interested in dating Tansy (guest star Mircea Monroe) and creates a basket that he hopes she will bid on.
Fast-talking New Yorker and brand new doctor Zoe Hart has it all figured out - after graduating top of her class from medical school, she'll follow in her father's footsteps and become a cardio-thoracic surgeon. But when her dreams fall apart, Zoe decides to accept an offer from a stranger, Dr. Harley Wilkes, to work with him at his small practice in Bluebell, Alabama. Zoe arrives in this small Gulf Coast town only to find that Harley has passed away and left his half of the medical practice to her in his will.
She quickly finds that Southern hospitality isn't always so hospitable - the other doctor in town, Brick Breeland, is less than pleased to be sharing the practice with this young outsider, and his daughter, Lemon, is a Southern belle whose sweet disposition turns sour when she meets Zoe. Zoe's only allies are the mayor, former football star Lavon Hayes, her bad-boy neighbor Wade Kinsella, and handsome lawyer George Tucker - who just happens to be Lemon's fiance. Zoe is out of her element and ready to pack her bags, but a surprise visit by her snobby New York mother leads to Zoe's decision to stay in Bluebell for a while, discovering small-town life and a side of herself she hadn't known was there.