With the sudden nuptials of Wanda (guest star Mallory Moye) and Tom (guest star Ross Philips) in BlueBell, Zoe agrees to be maid of honor, which entails the difficult job of watching Wanda's crafty mother. Zoe uses her wedding duties to try to avoid the awkwardness between her and Wade, but has a feeling something is wrong. Lemon faces the memory of being left at the altar and decides to take matters into her own hands. Meanwhile, Lavon hears about the neighboring town trying to build a shopping mall next to their local beach and he enlists George's help to fight it, but an unexpected side of George rears its ugly head.
Fast-talking New Yorker and brand new doctor Zoe Hart has it all figured out - after graduating top of her class from medical school, she'll follow in her father's footsteps and become a cardio-thoracic surgeon. But when her dreams fall apart, Zoe decides to accept an offer from a stranger, Dr. Harley Wilkes, to work with him at his small practice in Bluebell, Alabama. Zoe arrives in this small Gulf Coast town only to find that Harley has passed away and left his half of the medical practice to her in his will.
She quickly finds that Southern hospitality isn't always so hospitable - the other doctor in town, Brick Breeland, is less than pleased to be sharing the practice with this young outsider, and his daughter, Lemon, is a Southern belle whose sweet disposition turns sour when she meets Zoe. Zoe's only allies are the mayor, former football star Lavon Hayes, her bad-boy neighbor Wade Kinsella, and handsome lawyer George Tucker - who just happens to be Lemon's fiance. Zoe is out of her element and ready to pack her bags, but a surprise visit by her snobby New York mother leads to Zoe's decision to stay in Bluebell for a while, discovering small-town life and a side of herself she hadn't known was there.