After Jane is struck with inspiration for her book, she immediately begins to write, but her next challenge is to get an agent. Rogelio has been so focused on being the star, he begins to contemplate taking on a different role instead. Meanwhile, Jane thinks it's important to build a different relationship with the twins and turns to Petra for some guidance.
Set in Miami, the series details the surprising and unforeseen events that take place in the life of Jane Villanueva, a hard-working, religious young Latina woman whose family tradition and a vow to save her virginity until her marriage to a detective is shattered when a doctor accidentally artificially inseminates her by mistake during a checkup. And to make matters worse, the biological donor is a married man, a former playboy and cancer survivor who is not only the new owner of the hotel where Jane works, but was also her former teenage crush.