When Jane's editor pitches her a dark twist for her book, Jane begins to wonder if the same thing might have actually happened to her. Rogelio helps River bond with her daughter, but River once again makes things difficult for him. To avoid thinking about her career change, Xo instead focuses on trying to smooth things over between Jane and Alba. Meanwhile, Alba stands up to someone from her past, which helps Jane realize she should do the same for herself.
Set in Miami, the series details the surprising and unforeseen events that take place in the life of Jane Villanueva, a hard-working, religious young Latina woman whose family tradition and a vow to save her virginity until her marriage to a detective is shattered when a doctor accidentally artificially inseminates her by mistake during a checkup. And to make matters worse, the biological donor is a married man, a former playboy and cancer survivor who is not only the new owner of the hotel where Jane works, but was also her former teenage crush.