Jane struggles with giving Rafael his space after she discovers that he is hiding a secret. Jane and Michael uncover clues about what happened the day he "died". Petra wants to fit into JR's world and enlists Jane's help. After a few attempts to get back into the groove, Xo and Rogelio work together to try and find a new normal. Meanwhile, Alba confesses her feelings about Jorge.
Set in Miami, the series details the surprising and unforeseen events that take place in the life of Jane Villanueva, a hard-working, religious young Latina woman whose family tradition and a vow to save her virginity until her marriage to a detective is shattered when a doctor accidentally artificially inseminates her by mistake during a checkup. And to make matters worse, the biological donor is a married man, a former playboy and cancer survivor who is not only the new owner of the hotel where Jane works, but was also her former teenage crush.