After talking to everyone else about what is going on in her life, Jane turns to Petra, who she knows will give her a straight answer. In return, Petra leans on Jane for advice about JR. Xo is determined to be at grandparents' day for Mateo but still has one more chemo treatment. Meanwhile, Alba is getting mixed messages from Jorge about their relationship.
Set in Miami, the series details the surprising and unforeseen events that take place in the life of Jane Villanueva, a hard-working, religious young Latina woman whose family tradition and a vow to save her virginity until her marriage to a detective is shattered when a doctor accidentally artificially inseminates her by mistake during a checkup. And to make matters worse, the biological donor is a married man, a former playboy and cancer survivor who is not only the new owner of the hotel where Jane works, but was also her former teenage crush.