On the way to Jubilife City, Team Rocket captures Pikachu and flies off. After Starly pops the balloon, a wild Turtwig sends Team Rocket blasting off before running into the woods with the injured Pikachu. Ash, Brock, and Dawn meet Clara who lives on the lake and she explains that Turtwig helps injured pokémon and tires to keep peace in the forest. Ash, Brock, and Dawn go into the woods to find Pikachu and Turtwig, and Team Rocket is planning on stealing both.
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.