Ash and friends arrive in the town where Dawn will enter her next Pokémon Contest. They find out that a lot of people have come to the town in order to see the legendary Pokémon Phione, who lives in the surrounding sea. Legend has it that anyone who sees Phione will have good luck, so Dawn decides to try and catch a glimpse of it.
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.