Ash is training at Cynthia’s Villa when Ridley arrives thinking that ash had taken Meloetta away from him. After apologising for his mistake, Team Rocket arrives to take Meloetta. Ash and Meloetta try to get away from the Villa but they are captured by Giovanni. They are then taken to the undersea ruins.
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.