Ash, Brock, and Misty meet up with a witch named Lily. She is seeking ingredients to conduct a spell to make humans more friendly with Pokemon. The one last ingredient she needs is tears of an Aipom, and the group fights Team Rocket to get an Aipom. Lily then conducts the spell, turning Ash into a Pikachu!
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.