Our three heroes have lost their way in the depths of a dense wood, shrouded in thick, white mist. Momentarily giving up, they decide to break for a brief rest. As Ash wanders deeper into the wood, searching for firewood, he happens across a young boy being bullied by five classmates gathered around him. Eavesdropping on their conversation, Ash learns that the boys are attending the Pokémon Seminar (or 'Pokémon Zem' for short) - a preparatory school for Pokémon trainers. Graduates from the Pokémon Seminar are automatically qualified to participate in the Pokémon League without undergoing any actual test of skill. Although many children dream of entering the illustrious Seminar (or rather their parents dream of them entering), only the most wealthy children can enter the school. But there must be a reason for the gloom overshadowing the faces of the students of this aristocratic school.
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.