As Ash, Misty and Brock are walking through town looking for the Violet City gym, a little girl and boy are seen fighting over Pikachu. The kids, by continually grabbing and poking Pikachu, make him launch an all-out thunderbolt attack. Ash quickly picks him up, but although saving the kids from Pikachu's attack, he takes the full brunt of it. A rather attractive woman then comes running out, calling for Zackie and Lizy (the boy and girl fighting over Pikachu). Upon learning that our friends were on their way to the Violet City gym, she introduces herself as Miss Priscilla, a teacher from the Pokémon Academy.
A young boy named Ash Ketchum embarks on a journey to become a "Pokemon Master" with his first Pokemon, Pikachu. Joining him on his travels are Brock, a girl-obsessed Rock Pokemon Trainer, and Misty, a tomboyish Water Pokemon Trainer who may have a crush on him. Ash and Co. end up traveling through various regions, including Kanto, the Orange Islands, and Johto, and then enter the Pokemon League competitions there.
Along the way, they run into many confrontations with Jessie, James, and Meowth, a trio of Pokemon thieves who are apart of an evil organization called "Team Rocket". But every time Team Rocket try to do their evil deeds, they fail thanks to Ash and his Pokemon.