Medics from Holby head for France to offer their expertise to migrants stranded at a refugee camp. There, Alicia takes a shine to British medic Cameron Hamilton, who has been on the scene for a while, helping the camp's women and children. Meanwhile, Dylan finds himself becoming emotionally involved in the plight of two Sudanese orphans, who have fallen prey to ruthless people-traffickers, and back at the hospital, Connie is shocked to learn Sam has resigned and seems to have disappeared - taking Grace with him
The team of Holby medics continue their efforts to help migrant refugees in need of medical attention on the French coast. However, Dylan is fast becoming frustrated with how little he can offer the camp, and makes a decision he may come to regret. Meanwhile, back in the UK, Jez faces the repercussions of crossing paths with the Ellissons, as an improvised explosive is thrown through the window of his home, placing both Robyn and baby Charlotte in jeopardy.
The coroner's report into Scott Ellisson's death is due to arrive, and Ethan hopes that - whatever the outcome - the result will allow him to move on with his life. While a conflicted Ethan struggles with his guilt, Lily realises she needs to find a new date for her cousin's wedding, and Iain agrees to step in, but when the pair break down en route to the event, nothing can save them from the ire of Lily's domineering Aunt Ling. Elsewhere, intensifies his search for Sanosi's missing uncle, but finds himself in mortal danger after he pursues a thief onto a dilapidated boat.
Dylan is finally successful in reuniting Sanosi with his uncle Kamal. However, the reunion of the two families proves far from successful when Kamal is rushed to hospital suffering from abdominal pains that turn out to have been caused by his swallowing bags of heroin. Alicia wants to learn to drive to improve her career prospects and Elle offers to give her a lesson - which ends in a collision
A familiar face returns under a different guise, while Elle questions how happy she is being a single mother.
An anxious Connie focuses on Ethan's consultancy revision while waiting for the results of her tests. Elle meets a potential love interest.
Connie struggles to deal with the results of her scans and what it means for her future. Dylan is forced to bring Sanosi into the ED.
The truth finally catches up with Connie, as her symptoms begin to manifest, and Ethan realises she is the mystery 'heart patient' she has been quizzing him about. Determined to keep her illness under wraps, Connie blackmails Ethan into performing an urgent surgical procedure on her himself. Meanwhile, the day of Alicia's driving test arrives, but nerves get the better of her when she accidentally runs over her instructor's foot during one last lesson
Connie distracts herself from her personal problems by trying to get to the bottom of the squabbles between Dylan, David and Louise, who have been in conflict over Dylan's decision to smuggle Sanosi into the UK. Meanwhile, Lily is made uneasy by the natural chemistry between Sam and Iain, who she discovers have a romantic history together, and Max tries to deliver bad news to mortuary assistant Tara, whose new squeeze seems to have a troubling secret
Dylan helps a patient who was placed into foster care to protect her from her mother's abusive partner, and the encounter makes him realise that he must do what it right for Sanosi - even if it isn't always the easy thing. Meanwhile, Elle's new beau Marty receives a rude awakening when her sons catch them together in bed, and what was already a tense situation becomes even more awkward when he turns up at the hospital seeking help with a particularly sensitive problem
Rash, a new junior doctor, prepares to begin work in Holby's emergency department, but his first day gets off to a bad start when his mother nearly runs over Connie while dropping him off at the hospital. Meanwhile, Lily faces the tough decision of whether to stay put at Holby - where she can continue to pursue romance with Iain - or take the research position in Hong Kong
Ethan realises someone knows he let Scott Ellisson die after a sinister note is left in his locker. His first suspect is Connie, but when he discovers she has resigned herself to meeting an early demise, he turns his attention away from his own problems and tries to change her mind. Meanwhile, a vigilante and the suspected paedophile she was 'bringing to justice' are both admitted to the ED, David tries to help Rash overcome his nerves, and Robyn plans a christening for baby Charlotte
The day of Charlotte's christening arrives, and when a flustered Robyn steps into the ED staff room, she finds herself face-to-face with Glen - the terminally ill fiance who jilted her at the altar - very much alive. Naturally, Robyn has a few questions, and Dylan fills in the blanks by flashing back to the morning after Charlie's stag do, when he found a depressed Glen drinking away his woes in a rough karaoke bar. Determined to convince him not to give up on life, Dylan enlists the aid of his feisty old university tutor Zsa Zsa Harper-Jenkinson - an eminent brain surgeon in the US - to assess Glen's case. She reveals that pioneering surgery could save Glen, but the risks are high. However, with Dylan's help, Glen realises the birth of his daughter has given him a new purpose in life and a fresh dream to chase.
Connie attends her first day of chemotherapy, and in her absence, she places Ethan in charge of the ED. However, his overly thorough approach causes delays, and when the situation gets on top of him, it is up to Duffy to give him a tough love pep talk. Meanwhile, Robyn is dismayed to learn Glen has taken a job as a porter in the department, but he manages to prove his worth dealing with an injured priest with a suspicious fixation on antibiotics.
Connie's illness has a noticeable effect on her work, and even as she continues to brush away help from Charlie, her presence in the ED places her at greater risk of infection. Meanwhile, Ethan shows up late for his practical consultancy exam, and the arrival of new coffee shop worker Polly looks set to signal an improvement in Max's love-life, until he makes an excruciating faux pas while trying to flirt
Elle has a shock in store for Jacob. Rash questions his future as a doctor after treating an old girlfriend.
Connie struggles to keep her secret when going the extra mile for a patient leaves her in terrible danger.
Complications arise with Connie's illness, and she persuades Ethan to drive her to London to seek advice from a top consultant.
Max is reunited with James, and old friend from medical school, who enters the ED with his fiancee Aisha after she falls victim to a seemingly spontaneous acid attack. The encounter also gives him cause to re-evaluate his relationship with his estranged wife Zoe, who has arrived at the hospital seeking a reconciliation. Meanwhile, Elle reveals she wants to tell Blake that Jacob is his father, and when the lad is admitted to the department with a compass stuck through his hand, now seems as good a time as any
Elle panics when she wakes one morning to find Blake has not been home, and an already tense situation is made worse when he arrives in the ED with his friend Miles, who has been beaten unconscious. The teen claims burglars broke into Miles's flat and attacked him, but Jacob - already aware that Miles had been bullying Blake - smells a rat. Meanwhile, Connie makes a surprise return to the department ahead of Ethan's consultancy exam, and Robyn, David and Glen rally round to cheer up Noel, who is missing Max
Dylan struggles to keep his alcoholism under control, as staff on the ED deal with what is suspected to be a case of domestic abuse. Meanwhile, Ethan's first day as Clinical Lead fails to go according to plan, as he finds himself veering wildly from one disaster to another, and he starts to understand the real pressure of leading a team
Alicia takes matters into her own hands when queuing ambulances put patients in danger, while new F1 Bea gets a rude awakening on her first day.
On the day of her son's trial, Elle finds herself looking after the boy he assaulted. Are his new injuries related? Bea's one-night stand leads her to find out Rash's secret.
Under-pressure Ethan makes a decision that exposes the weaknesses of the ED and gives ammunition to the anonymous blogger. It is Gem's first day as a porter.
Ethan is stunned when hospital administrators reveal the ED's budget is in a poor state, and as he struggle to balance the books, he begins to compromise care for his patients. Determined to do what is best for those in his care, he makes an unpopular decision. Meanwhile, Glen becomes uncomfortable with the idea that his daughter doesn't share his surname, and decides the best course of action is to propose to Robyn. However, his decidedly unromantic gesture has predictably bad results.
Joseph, a man from Dylan's AA group, is admitted to the ED having suffered a stroke following a one-night stand with Ciara, a fellow member and self-described `fun drunk'. When Joseph's condition deteriorates, Dylan must decide whether exposing the pair's affair is more important than keeping Ciara on the path to recovery. Meanwhile, Ethan becomes convinced that ambitious new doctor Bea is the author of the Rage in Resus blog, and Rash earns the contempt of the auxiliary staff when he makes an unfair presumption about Gem after spotting her with his wallet.
Jac Naylor arrives in the ED and sets an ultimatum. CEO Serena Campbell wants the Rage in Resus blog to be shut down by the end of the day or its author - and Ethan - will be fired. A pressurised Ethan confronts Alicia and asks if she is responsible for the blog, but she denies everything. Elsewhere, an overweight girl helps her bullying sister with her gymnastic training, and a 12-year-old is brought into the ED after spending the night in an underpass.
Rash's new-found confidence is tested by a prisoner, who also leads Gem into danger. Bea goes up against confident F1 Eddie for a coveted training course.
The day of Robyn and Glen's wedding arrives, but the groom has a seizure while getting ready at the hotel. Dylan performs a CT scan on him that confirms his cancer has returned, but he keeps quiet and gets through the ceremony, with tragedy striking as the couple depart for their honeymoon. Rash treats a woman suffering from anxiety after the death of her fiance.
Glen and Robyn are both rushed to the ED, where he finally tells her the truth about his seizures and agrees to undergo an MRI scan. Bea grows concerned that Dylan's alcoholism may be affecting his judgement and asks to shadow him. The pair treat a young woman who is suffering chest pain and is convinced she has tuberculosis.
Ethan treats a pregnant woman who was rushed to the ED after her waters broke at a bus stop. However, as he learns more about her, he realises she is related to his brother's hugger. Elsewhere, Iain jokes with Sam about her failure to ask Dylan out for a meal. She then admits that she is worried about Dylan's alcoholism, and wants to help him.
Bea treats a shopkeeper who has collapsed during a robbery, but faces a dilemma when she begins to suspect two brothers in her care are the men responsible for the crime. Rash begins to worry that she is struggling to cope with the pressures of her new responsibilities. Ethan provides treatment for Leigh-Anne's baby, who is having trouble breathing, and ends up confessing his guilt over failing to save her partner.
Ethan is in danger of crossing a line with Leigh-Anne, while Robyn throws away a present from Glen after he questions whether she is fit to be in work. Bea wakes up in an alley calling for help, which comes in the form of nightclub bouncer Johnny, who initially refuses treatment for his own nasty cut.
Connie returns as clinical lead, with a big plan for the hospital. Ethan comes to the aid of a severely distressed Leigh-Anne. Alicia holds a party at her new flat.
Iain and Sam, neck-deep in water and running out of time, are forced to make a life-changing decision. When Bea's secrets are revealed, she finally has to confront her demons.
Iain and Sam find a confused woman with deep lacerations to her head wandering the streets, and when they take her into the ED, Connie instantly recognises her as a friend from chemotherapy. Bea struggles to regain her confidence on her first day back at work, while Alicia and Ethan have a heart-to-heart and agree to be friends again.
Alicia struggles to process the events of her night with Eddie, and collapses at work after refusing to take a break. Just as she starts to open up to Ethan about her problems, Elle interrupts. A girl breaks out of her house to run away with her boyfriend, but the coach they are travelling on crashes, while Jacob is determined to get Blake to study.
Eddie realises Alicia is scared of him after discovering that she has swapped all her shifts to avoid him. Meanwhile, Bea receives a phone call about her dad and leaves work to pick him up from the police station, and Sam and Jacob discuss which of the ED staff she would be able to beat in a boxing match.
With Dylan nowhere to be found, Connie and Elle are forced to work together to pitch for funding for a new trauma centre. With both women struggling to hide their resentment of each other, their relationship hits rock bottom. Elsewhere, Bea grows concerned for Alicia, while Gem and Rash are tasked with looking after Connie's goldfish.
Struggling to keep a lid on her emotions following her night with Eddie, Alicia pushes Ethan away. She then has to deal with Leigh-Anne, who arrives in the ED with her son Kiegan, but a shocking confession from Ethan leaves her feeling even more alone. Connie returns and immediately notices that someone has killed her goldfish and replaced it. With Elle's encouragement, Connie has some fun waiting for the culprits to reveal themselves and puts the pressure on. Elsewhere, Robyn asks for more overtime due to her parking fines.
A first day from hell pushes new paramedic Ruby to her limits and beyond. Bea forces Alicia to face a crippling truth.
Bea tries to give Alicia the help she needs following the attack, while Eddie tries to rebuild their relationship - only to be told they are purely professional colleagues. Jacob lies to Sam and tells her that Blake knows about their relationship. Elsewhere, after overhearing Sam express her doubts that she will last another shift, Ruby attempts to build bridges with her colleagues and patients. A father and son are brought in with injuries they refuse to explain, raising suspicions of abuse - but it is not clear who is the abuser and who the victim.
Alicia finds herself on a collision course with Bea after deciding not to report her rape. Connie clashes with Elle when she puts a patient in danger.
Alicia plucks up her courage to tell the police that she has been raped. Eddie accompanies the paramedics who are called out to treat Jon's wife after she suffers serious burns - and is arrested on his return to the hospital. Bea leaves to make a fresh start in Paris, and Alicia receives an unwelcome visit that has devastating consequences.