The ED struggles without Charlie who is recuperating as he encounters a young mum who leaves her baby with him.
Charlie returns to work as new nurse Colette starts work and it proves to be tough.
It is another busy day as a young girl who drinks heavily causes a car crash as Baz plans to move to Canada.
The press have got wind that a nurse is HIV+ as the journalist involved gets checked in as a patient.
Journalists try to get into the department to hear more about Adam as Charlie has to bring Louis into work with him.
Annoyed with the press attention, Adam decides to resign as Josh survives a cliffside rescue.
The ED sees the arrival of asylum seekers who get support from Max as Louis is brought into work again.
For Josh, Fin, Penny and Mel, it is a busy shift as they transport patients to the ED.
Josh and Fin have a passenger in the form of Patrick who isn't the best of passengers as Chloe has troubles.
Duffy's husband Andrew is due to return to work at Holby as Fin learns that Mel is affraid of dogs.
Fin and Mel are in the ED observing how things work as Duffy celebrates her birthday.
Andrew Bower returns to work in the ED as Duffy struggles to work alongside him on an eventful shift.
The "Well Teddy Clinic" has the full support of directorate manager Dan Robinson but Holly's enthusiasm fails to rub off on the rest of her colleagues.The project gets more backing, however, when Patrick and Max notice the young attractive teacher Laura with the children. Schoolgirl Michelle follows Patrick around adoringly and even names her Teddy bear after him. Nurses Chloe and Barney both have interviews for the E-grade nursing position. Chloe is dreading the interview while Barney appears to be taking it all in his stride. Charlie is reluctantly arranging a flight to take Louis over to Toronto to join Baz. Duffy seems in better spirits now that her husband has settled into the department but can't understand why she is feeling so tired all the time. Colette cringes with embarrassment when one of her ex-boyfriends, Declan accompanies his wife Ashley into Casualty. Ashley had cosmetic surgery which has become infected. Will Declan recognize this as a cry for help and realize the err
Duffy isn't feeling well as Barney isn't too pleased about working with Spencer.
Andrew deals with a family when a mother is admitted but believes the father to be dead but he is still alive as Barney tries to apologise to Chloe over Spencer.
Arriving for work after spending the night in jail, Barney has some explaining to do as an elderly gentleman has a change of heart at Christmas.
This episode is at Christmas. Holly and Patrick have gone out to lunch to celebrate. All through the meal Patrick is grumpy and Holly gets really annoyed with him and starts to wish she had not brought him.
New Years Eve in Holby sees Max trying to help a drug addict by giving him clean needles as Spencer tries to call a truce with Barney.
Josh and Penny are down at the sports centre running a stall with help from Chantelle as Charlie plans to fight for custody over Louis.
Andrew is worried that they're too old for a baby but Dully disagrees. When Chantelle's estranged father Jerry is hit by a cat she and Penny reach a decision about seeking out their natural fathers. Holly is still puzzled about the identity of her secret admirer. Casualty gets a full taste of girl power when a Spice Girls tribute band rush into A&E after "Baby Spice" is electrocuted by a faulty microphone. Things hot-up when "Posh Spice" tests positive for a pregnancy test and reveals that manager Leslie is the father, leaving "Ginger Spice" horrified because he's secretly been seeing her too.
After attending the funeral of a old navy pal, Spencer finds himself wrapped in a situation which leaves him and Patrick held prisoner.
It is a busy shift but things aren't helped by the concern that patients have contracted Legionnaire's as another patient's smoking causes trouble.
It is a busy shift for the staff as they deal with casualties from an explosion at the hotel which include an MP who has spoken out against the NHS.
Josh and Penny have a situation on their hands when a man threatens to jump of a building if his already dead brother dies as Charlie learns how much the custody battle will cost him.
Barney, Fin, Josh and Tom are transferring a burns patient to another hospital when a young lad jumps out needing help for his pregnant girlfriend who is in labour.
Charlie attends a court hearing and learns that fathers are rarely granted custody in cases like this as the department prepares to a major incident exercise.
The department is overstretched as Duffy recovers upstairs from her miscarriage scare and a meeting with Dan doesn't help Charlie's mood.
New student nurse Anna Paul starts work as Charlie has closed the department to all new patients causing trouble for Fin as Holly suspects one of her patients is her stalker.
Amy informs Duffy that today is her last day after what happened with Milo as Holly becomes more scared with the stalker situation.
Tom drives Holly home as suggests they go to his place which she agrees but Dan starts to figure out Tom is her stalker.
Jack Vincent starts work in the department as the new receptionist as Holly returns to work, determined to shake off the incident with Tom.
Penny has a surprise visitor in the form of her half brother Luke as Duffy works her last shift before taking maternity leave.
Penny goes to visit her father's farm along with Fin but her father doesn't want to know as Chloe and Barney attend a wrestling match only for Chloe to be trapped during a fire.
After spending time getting to know her father, Penny is thinking about leaving to be with him as Chloe and Barney are praised for helping Louisa during the fire.
It is a busy shift for the department staff whilst at a school, a fight breaks out between two students as Penny prepares to leave Holby to join her father.
This was Holly's last ever episode. She is captured by Tom who smashes up her car and then takes her away to a disued part of the hospital. He makes her put on a silver dress and says they are going to die right now lying next to each other. However Patrick has realized that she is missing and goes of to look for her. Holly manages to throw a chair out of the window which atracts Patrick's attention. Patrick comes up to rescue her but before he arrives Tom injects her with something that will hug her. When Patrick arrives he chases away Tom and finds Holly unconsious. Patick gives Holly mouth to mouth and she comes round. They hug while Robbie Williams's Angels is playing.