Greg and Joseph have to retrieve a heart for a transplant but when they arrive at the hospital it quickly becomes apparent that everything is not well. After Elaine dies, Connie attempts to make peace with Kevin but she believes he is out for revenge. After Kevin ends up rescuing her from an attack by an ex-patient's relative Connie's hopes of them sorting out their problems are dashed by Kevin's subsequent character assassination of her. Connie ends up turning to Greg for some support.
This series is a spin-off from the long running BBC medical drama Casualty. Set in the same hospital as its sister series, this show follows the everyday lives, professional and personal, of the doctors, nurses and patients who find themselves, for various reasons, in the wards of Holby City General Hospital